Tissue Engineering therapies based on folic acid and other vitamin B derivatives. Functional mechanisms and current applications in Regenerative Medicine.

B-vitamins are a group of soluble vitamins which are cofactors of some of the enzymes involved in the metabolic pathways of carbohydrates, fats and proteins. These compounds participate in a number of functions as cardiovascular, brain or nervous systems. Folic acid is described as an accessible and multifunctional niche component that can be used safely, even combined with other compounds, which gives it high versatility. Also, due to its non-toxicity and great stability, folic acid has attracted much attention from researchers in the biomedical and bioengineering area, with an increasing number of works directed at using folic acid and its derivatives in tissue engineering therapies as well as regenerative medicine. Thus, this review provides an updated discussion about the most relevant advances achieved during the last five years, where folic acid and other vitamins B have been used as key bioactive compounds for enhancing the effectiveness of biomaterials’ performance and biological functions for the regeneration of tissues and organs.

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Fernández-Villa, D., Jiménez Gómez-Lavín, M., Abradelo, C., San Román, J. & Rojo, L. Tissue Engineering Therapies Based on Folic Acid and Other Vitamin B Derivatives. Functional Mechanisms and Current Applications in Regenerative Medicine. Int J Mol Sci 19, (2018). Cite

Bibliographic review on the state of the art of strontium and zinc based regenerative therapies. Recent developments and clinical applications

This review brings up to date the state of the art of strontium and zinc based regenerative therapies, both having a promoting effect on tissue formation and a role inhibiting resorption in musculoskeletal disorders.

 

Contribution of bioactive hyaluronic acid and gelatin to regenerative medicine. Methodologies of gels preparation and advanced applications

The functionality and reactivity of polysaccharides, and in particular hyaluronic acid, in combination with proteins like gelatin, collagen and many others, offer very interesting opportunities for the new trends in regenerative medicine. In this review is described the relevance of gelatin (Gel) and hyaluronic acid (HA) biopolymers in the field of tissue engineering due to the excellent response of these biomimetic materials and their bioactive and biodegradable character in the human body. In addition, it is reported an overview of the most relevant crosslinking processes and agents that are being developed for regenerative medicine, including different hydrogel modifications as well as several interesting and advanced applications. The growing of clinical applications of these macromolecular components as assemblies opens new and advanced opportunities in regenerative medicine and drug delivery fields.

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