La regeneración ósea guiada puede desempeñar un papel importante en aplicaciones ortopédicas. Este trabajo presenta la síntesis y caracterización de andamiajes compuestos basados en polisacáridos cargados con micropartículas de titanio o tántalo como materiales novedosos propuestos para sistemas compuestos con características prometedoras para la regeneración ósea guiada. Los andamiajes compuestos de Ti/Ta fueron sintetizados utilizando quitosano y goma gellan como sustratos orgánicos y entrecruzados con dextrano oxidado, resultando en compuestos inorgánico-orgánicos estables. La caracterización físico-química reveló una distribución uniforme de nanopartículas metálicas dentro de los andamiajes que mostraron una liberación de metales inferior al 5 %. Los ensayos biológicos in vitro demostraron que los compuestos de Ta exhiben una actividad de ALP dos veces mayor que los de Ti y una mayor capacidad para apoyar la diferenciación completa de células madre mesenquimales humanas en osteoblastos. Estos resultados destacan su potencial para aplicaciones en la regeneración ósea.
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