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1.
Asensio, G. et al. Strontium/zinc phytate-based self-assembled monolayers on titanium surfaces enhance osteogenesis and antibacterial performance in vitro. Applied Surface Science 620, 156818 (2023). Cite
1.
Rosado, A. et al. Facile, fast and green synthesis of a highly porous calcium-syringate bioMOF with intriguing triple bioactivity. Inorg. Chem. Front. 10, 2165–2173 (2023). Cite
1.
Halfter, N. et al. Ketoprofen-Based Polymer-Drug Nanoparticles Provide Anti-Inflammatory Properties to HA/Collagen Hydrogels. Journal of Functional Biomaterials 14, 160 (2023). Cite
1.
Caro-León Fj et al. DEAE/Catechol-Chitosan Conjugates as Bioactive Polymers: Synthesis, Characterization, and Potential Applications. Biomacromolecules 24, (2023). Cite
1.
Huerta-Madroñal, M., Espinosa-Cano, E., Aguilar, M. R. & Vazquez-Lasa, B. Antiaging properties of antioxidant photoprotective polymeric nanoparticles loaded with coenzyme-Q10. Biomaterials Advances 145, 213247 (2023). Cite
1.
Asensio, G., Martín-del-Campo, M., Ramírez, R. A., Rojo, L. & Vázquez-Lasa, B. New Insights into the In Vitro Antioxidant Routes and Osteogenic Properties of Sr/Zn Phytate Compounds. Pharmaceutics 15, 339 (2023). Cite
1.
Asensio, G. et al. A study on Sr/Zn phytate complexes: structural properties and antimicrobial synergistic effects against Streptococcus mutans. Sci Rep 12, 20177 (2022). Cite
1.
Fernández-Villa, D. et al. Development of Methotrexate Complexes Endowed with New Biological Properties Envisioned for Musculoskeletal Regeneration in Rheumatoid Arthritis Environments. Int J Mol Sci 23, 10054 (2022). Cite
1.
Rojo, L., García-Fernández, L., Aguilar, M. R. & Vázquez-Lasa, B. Antimicrobial polymeric biomaterials based on synthetic, nanotechnology, and biotechnological approaches. Current Opinion in Biotechnology 76, 102752 (2022). Cite
1.
Velasco-Salgado, C. et al. The Role of Polymeric Biomaterials in the Treatment of Articular Osteoarthritis. Pharmaceutics 14, 1644 (2022). Cite
1.
Advanced Polymers for Biomedical Applications. (MDPI - Multidisciplinary Digital Publishing Institute, 2022). doi:10.3390/books978-3-0365-4613-1. Cite
1.
Criado-Gonzalez, M. et al. Injectable Tripeptide/Polymer Nanoparticles Supramolecular Hydrogel: A Candidate for the Treatment of Inflammatory Pathologies. ACS Appl. Mater. Interfaces 14, 10068–10080 (2022). Cite
1.
Hernández-Sosa, A. et al. Optimization of the Rheological Properties of Self-Assembled Tripeptide/Alginate/Cellulose Hydrogels for 3D Printing. Polymers 14, 2229 (2022). Cite
1.
Rubio Hernández-Sampelayo, A. et al. Biodegradable and Biocompatible Thermoplastic Poly(Ester-Urethane)s Based on Poly(ε-Caprolactone) and Novel 1,3-Propanediol Bis(4-Isocyanatobenzoate) Diisocyanate: Synthesis and Characterization. Polymers 14, 1288 (2022). Cite
1.
Asensio, G. et al. Biomimetic Gradient Scaffolds Containing Hyaluronic Acid and Sr/Zn Folates for Osteochondral Tissue Engineering. Polymers 14, 12 (2022). Cite
1.
Escalante, S. et al. Chemically crosslinked hyaluronic acid-chitosan hydrogel for application on cartilage regeneration. Frontiers in Bioengineering and Biotechnology 10, (2022). Cite
1.
Lafuente-Merchan, M. et al. Chondroitin and Dermatan Sulfate Bioinks for 3D Bioprinting and Cartilage Regeneration. Macromolecular Bioscience n/a, 2100435 (2022). Cite
1.
Puertas-Bartolomé, M., Włodarczyk-Biegun, M. K., del Campo, A., Vázquez-Lasa, B. & San Román, J. Development of bioactive catechol functionalized nanoparticles applicable for 3D bioprinting. Materials Science and Engineering: C 131, 112515 (2021). Cite
1.
Vázquez, R. et al. DEAE-chitosan nanoparticles as a pneumococcus-biomimetic material for the development of antipneumococcal therapeutics. Carbohydrate Polymers 273, 118605 (2021). Cite
1.
Huerta-Madroñal, M., Caro-León, J., Espinosa-Cano, E., Aguilar, M. R. & Vázquez-Lasa, B. Chitosan – Rosmarinic acid conjugates with antioxidant, anti-inflammatory and photoprotective properties. Carbohydrate Polymers 118619 (2021) http://doi.org/10.1016/j.carbpol.2021.118619. Cite
1.
Yanes-Díaz, J. et al. Antitumor Activity of Nanoparticles Loaded with PHT-427, a Novel AKT/PDK1 Inhibitor, for the Treatment of Head and Neck Squamous Cell Carcinoma. Pharmaceutics 13, 1242 (2021). Cite
1.
Espinosa-Cano, E. et al. Hyaluronic acid (HA)-coated naproxen-nanoparticles selectively target breast cancer stem cells through COX-independent pathways. Materials Science and Engineering: C 124, 112024 (2021). Cite
1.
Fernández-Villa, D. et al. Vitamin B9 derivatives as carriers of bioactive cations for musculoskeletal regeneration applications: Synthesis, characterization and biological evaluation. European Journal of Medicinal Chemistry 212, 113152 (2021). Cite
1.
Pontes-Quero, G. M., Benito-Garzón, L., Pérez Cano, J., Aguilar, M. R. & Vázquez-Lasa, B. Amphiphilic polymeric nanoparticles encapsulating curcumin: Antioxidant, anti-inflammatory and biocompatibility studies. Materials Science and Engineering: C 121, 111793 (2021). Cite
1.
Pontes-Quero, G. M., Benito-Garzón, L., Pérez Cano, J., Aguilar, M. R. & Vázquez-Lasa, B. Modulation of Inflammatory Mediators by Polymeric Nanoparticles Loaded with Anti-Inflammatory Drugs. Pharmaceutics 13, 290 (2021). Cite
1.
Riestra-Ayora, J. et al. Paclitaxel-loaded polymeric nanoparticles based on α-tocopheryl succinate for the treatment of head and neck squamous cell carcinoma: in vivo murine model. Drug Delivery 28, 1376–1388 (2021). Cite
1.
Mora-Boza, A. et al. Microfluidics generation of chitosan microgels containing glycerylphytate crosslinker for in situ human mesenchymal stem cells encapsulation. Materials Science and Engineering: C 120, 111716 (2021). Cite
1.
Alkattan, R., Rojo, L. & Deb, S. Antimicrobials in Dentistry. Applied Sciences 11, 3279 (2021). Cite
1.
Puertas-Bartolomé, M., Mora-Boza, A. & García-Fernández, L. Emerging Biofabrication Techniques: A Review on Natural Polymers for Biomedical Applications. Polymers 13, 1209 (2021). Cite
1.
Pontes-Quero, G. M., Esteban-Rubio, S., Pérez-Cano, J., Aguilar, M. R. & Vazquez-Lasa, M. B. Oregano essential oil micro- and nanoencapsulation with bioactive properties for biotechnological and biomedical applications. Front. Bioeng. Biotechnol. 9, (2021). Cite
1.
Nakal-Chidiac, A. et al. Chitosan-stabilized silver nanoclusters with luminescent, photothermal and antibacterial properties. Carbohydrate Polymers 250, 116973 (2020). Cite
1.
Mora-Boza, A. et al. Microfluidics generation of chitosan microgels containing glycerylphytate crosslinker for in situ human mesenchymal stem cells encapsulation. Materials Science and Engineering: C 111716 (2020) http://doi.org/10.1016/j.msec.2020.111716. Cite
1.
Rivero-Buceta, V. et al. Anti-staphylococcal hydrogels based on bacterial cellulose and the antimicrobial biopolyester poly(3-hydroxy-acetylthioalkanoate-co-3-hydroxyalkanoate). International Journal of Biological Macromolecules 162, 1869–1879 (2020). Cite
1.
Mora-Boza, A. et al. Evaluation of Glycerylphytate Crosslinked Semi- and Interpenetrated Polymer Membranes of Hyaluronic Acid and Chitosan for Tissue Engineering. Polymers 12, 2661 (2020). Cite
1.
Cifuentes, A. et al. Chitosan hydrogels functionalized with either unfractionated heparin or bemiparin improve diabetic wound healing. Biomedicine & Pharmacotherapy 129, 110498 (2020). Cite
1.
Pérez de Vega, M. J. et al. Characterization of Novel Synthetic Polyphenols: Validation of Antioxidant and Vasculoprotective Activities. Antioxidants 9, 787 (2020). Cite
1.
Lagos, S. I. Z. et al. Influence of the chitosan morphology on the properties of acrylic cements and their biocompatibility. RSC Adv. 10, 31156–31164 (2020). Cite
1.
Mora-Boza, A. et al. Glycerylphytate crosslinker as a potential osteoinductor of chitosan-based systems for guided bone regeneration. Carbohydrate Polymers 241, 116269 (2020). Cite
1.
Espinosa-Cano, E., Aguilar, M. R., Portilla, Y., Barber, D. F. & San Román, J. Anti-Inflammatory Polymeric Nanoparticles Based on Ketoprofen and Dexamethasone. Pharmaceutics 12, 723 (2020). Cite
1.
Fernández-Gutiérrez, M. et al. Development of Biocomposite Polymeric Systems Loaded with Antibacterial Nanoparticles for the Coating of Polypropylene Biomaterials. Polymers 12, 1829 (2020). Cite
1.
García-Fernández, L. et al. Injectable hydrogel-based drug delivery system for cartilage regeneration. Materials Science and Engineering: C 110, 110702 (2020). Cite
1.
Martín-del-Campo, M., Fernández-Villa, D., Cabrera-Rueda, G. & Rojo, L. Antibacterial Bio-Based Polymers for Cranio-Maxillofacial Regeneration Applications. Applied Sciences 10, 8371 (2020). Cite
1.
Zapata, M. E. V. et al. Osseointegration of Antimicrobial Acrylic Bone Cements Modified with Graphene Oxide and Chitosan. Applied Sciences 10, 6528 (2020). Cite
1.
Pontes-Quero, G. M. et al. Characterization Techniques for Emulsion-Based Antioxidant Carriers with Biomedical Applications. in Emulsion‐based Encapsulation of Antioxidants: Design and Performance (ed. Aboudzadeh, M. A.) 423–462 (Springer International Publishing, 2020). doi:10.1007/978-3-030-62052-3_12. Cite
1.
Asensio, G. et al. Adhesivos poliméricos en biomedicina: apósitos, reparaciones quirúrgicas y reconstrucciones dentales. Revista de plásticos modernos: Ciencia y tecnología de polímeros 120, 4 (2020). Cite
1.
Espinosa‐Cano, E., Aguilar, M. R., Portilla, Y., Barber, D. F. & Román, J. S. Polymeric Nanoparticles that Combine Dexamethasone and Naproxen for the Synergistic Inhibition of Il12b Transcription in Macrophages. Macromolecular Bioscience 20, 2000002 (2020). Cite
1.
Mora-Boza, A., Włodarczyk-Biegun, M. K., Campo, A. del, Vázquez-Lasa, B. & Román, J. S. Glycerylphytate as an ionic crosslinker for 3D printing of multi-layered scaffolds with improved shape fidelity and biological features. Biomater. Sci. 8, 506–516 (2020). Cite
1.
Puertas-Bartolomé, M. et al. Bioadhesive functional hydrogels: Controlled release of catechol species with antioxidant and antiinflammatory behavior. Materials Science and Engineering: C 105, 110040 (2019). Cite
1.
Asensio, G., Vázquez-Lasa, B. & Rojo, L. Achievements in the Topographic Design of Commercial Titanium Dental Implants: Towards Anti-Peri-Implantitis Surfaces. Journal of Clinical Medicine 8, 1982 (2019). Cite
1.
Al-Khoury, H. et al. Anti-inflammatory Surface Coatings Based on Polyelectrolyte Multilayers of Heparin and Polycationic Nanoparticles of Naproxen-Bearing Polymeric Drugs. Biomacromolecules 20, 4015–4025 (2019). Cite