Mediante el uso de una malla de PET como soporte durante el proceso de electrospinning se pueden obtener redes de microfibras con estructuras 3D. El uso de copolímeros tribloque biodegradables basados en copolímero aleatorio de ácido poliláctico y succinato / azelato de poli (butileno) presentan un excelente proceso de biodegradación controlada en condiciones fisiológicas, con interesantes aplicaciones en el direccionamiento y la liberación controlada de diferentes fármacos.
Después de la aplicación de la malla de PET en el proceso de electrospinning se obtiene una red de microfibras orientadas de forma específica. Además las redes de microfibras se cargaron con dexametasona como fármaco antiinflamatorio. La liberación del fármaco tiene lugar en un período relativamente corto debido a la formación de cristales de fármaco en la superficie de las fibras durante el proceso de electrospinning. Este problema puede ser restringido actuando sobre la composición de copolímero tribloque, mejorando la compatibilidad fármaco-polímero. La copolimerización también permite la modulación de la tasa de biodegradación. Por lo tanto, estos soportes biodegradables pueden considerarse muy prometedores en el campo de la medicina regenerativa y la ingeniería de tejidos.
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