En este artículo, se describe una estrategia optimizada de síntesis del potente compuesto anticancerígeno 4,7-dicloro-2-quinolinometanol (QM) y su éster acrilato 4,7-dicloro-2-quinolinilacrilato de metilo (AQM). AQM se copolimeriza utilizando polimerización por radicales libres con N-vinil-2-pirrolidona (VP). Los copolímeros preparados con diferentes proporciones molares de los comonómeros en la alimentación se someten a nanoprecipitación para obtener suspensiones de nanopartículas (NP) en solución salina tamponada con fosfato (PBS). Las NP más pequeñas y estables se obtienen con los copolímeros AQM-VP 45:55 y 40:60 (118.9 y 128.7 nm de diámetro, respectivamente) a 1 mg/mL, y junto con el AQM y QM, se evalúa su actividad citotóxica en células de carcinoma de mama MDA-MB-453 mediante un ensayo in vitro de MTT. Así pues, el AQM y QM resultan altamente citotóxicos (IC50: 19 y 41 µM, respectivamente); sin embargo, las NP no son citotóxicas en el rango de concentraciones ensayadas. Estos resultados contribuyen a la búsqueda de nuevas NP poliméricas con aplicaciones potenciales como sistemas de liberación de QM para el tratamiento de cáncer u otras enfermedades tratables con QM.
3729048
{3729048:5IMVZAXZ}
nature
50
1
1
title
578
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