La osteoartrosis es una enfermedad degenerativa crónica de progresión lenta que constituye un grave problema clínico y de salud pública. Los tratamientos clínicos actuales disponibles son incapaces de revertir la progresión de la enfermedad, por lo que hoy en día se intentan desarrollar sistemas alternativos para evitar o retrasar la aplicación de procedimientos quirúrgicos. En este trabajo, los sistemas de administración de fármacos inyectables cargados con naproxeno o dexametasona se formularon como hidrogeles de gelatina y ácido hialurónico que forman una estructura de red semi-interpenetrante (semi-IPN). Este estudio se centra principalmente en la caracterización fisicoquímica de estos hidrogeles, el análisis in vitro y el rendimiento in vivo después de la inyección en rodillas de conejo con osteoartrosis. Los resultados indican que existe una estrecha relación entre la liberación del fármaco y la degradación del hidrogel. Todos los hidrogeles son citocompatibles y presentan una nula toxicidad. Los resultados in vivo revelan que ambos hidrogeles promueven la regeneración del cartílago después de su inyección en rodillas con osteoartrosis.
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