Las nanopartículas poliméricas son excelentes vehículos de fármacos para el tratamiento y el diagnóstico de cáncer. En comparación con otras nanopartículas inorgánicas, los nanovehículos poliméricos presentan notables ventajas en términos de estabilidad, biocompatibilidad, biodegradabilidad, capacidad de adaptación y bajo coste. Las nanopartículas poliméricas pueden además diseñarse para acumularse pasiva o activamente en tejidos tumorales controlando sus propiedades hidrodinámicas o funcionalizando su superficie con moléculas diana.
Adicionalmente, los polímeros que responden a condiciones específicas de los tejidos tumorales como un pH reducido, altos niveles de especies reactivas de oxígeno o enzimas sobreexpresadas pueden utilizarse para desencadenar una liberación controlada y más efectiva de fármacos así como para potenciar el efecto terapéutico de un sistema teranóstico.
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Espinosa-Cano, E., Palao-Suay, R., Aguilar, M. R., Vázquez, B. & Román, J. S.
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Nanooncology 137–172 (Springer, Cham, 2018). doi:10.1007/978-3-319-89878-0_4.
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