El objetivo de este trabajo es estudiar, en un modelo in vitro de carcinoma de células escamosas de cabeza y cuello, las propiedades anti-angiogénicas y anti-migratorias de nanopartículas poliméricas autoensambladas (NPs) con actividad anticancerígena selectiva. Las NPs se basan en el succinato de α-tocoferilo (α-TOS) que se encapsula en su núcleo hidrofóbico. El efecto de estas NPs se evalúa en células endoteliales en proliferación y células escamosas de carcinoma de hipofaringe, incluyendo marcadores de angiogénesis, apoptosis y especies reactivas de oxígeno (ROS).
Las NPs cargadas con α-TOS suprimieron la angiogénesis, induciendo la acumulación de ROS y la apoptosis de células endoteliales en proliferación. Además, también disminuyeron el número y la calidad de los tubos tipo capilar en un experimento tridimensional (3D) in vitro, disminuyeron la producción del factor de crecimiento endotelial vascular proangiogénico y regularon negativamente la expresión de su receptor. La eficacia antimigratoria de α-TOS se corroborró en células de carcinoma de hipofaringe al disminuir la secreción de metaloproteasas de matriz 2 y 9 (MMP-2 y MMP-9) e inhibir la migración celular. Estos resultados confirman que las NPs basadas en α-TOS no solo presentan propiedades anticancerígenas, sino también propiedades anti-angiogénicas, por lo que son candidatos prometedores para nuevas terapias contra el cáncer.
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