Los defectos óseos orales ocurren como resultado de traumatismos, cáncer, infecciones, enfermedades periodontales y caries. Los injertos autógenos y alógenos son el estándar de oro utilizados para tratar y regenerar segmentos óseos dañados o defectuosos. Sin embargo, estos materiales no poseen las propiedades antimicrobianas necesarias para inhibir la invasión de los numerosos patógenos perjudiciales presentes en la microbiota oral. En el presente estudio, poli(ε-caprolactona) (PCL), nano-hidroxiapatita (nHAp) y un extracto comercial de Humulus lupulus L. (lúpulo) fueron electrohilados en matrices poliméricas para evaluar su potencial para la liberación de fármacos y la regeneración ósea. Las matrices fabricadas fueron analizadas mediante microscopía electrónica de barrido (SEM), análisis de tracción, análisis termogravimétrico (TGA), ensayo FTIR y degradación hidrolítica in vitro. Las propiedades antimicrobianas fueron evaluadas contra los patógenos orales Streptococcus mutans, Porphyromonas gingivalis y Aggregatibacter actinomycetemcomitans. La citocompatibilidad fue demostrada utilizando el ensayo MTT. El análisis SEM estableció la presencia de matrices nanoestructuradas en una red tridimensional interconectada. La presente investigación proporciona nueva información sobre la interacción de compuestos naturales con biomateriales cerámicos y poliméricos. El extracto de lúpulo y otros agentes medicinales naturales o sintéticos pueden ser cargados eficazmente en las fibras de PCL y tienen el potencial de ser utilizados en aplicaciones orales.
3729048
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nature
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title
1549
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