A pesar de las impresionantes características de los marcos orgánicos metálicos biológicos (bioMOFs) para su uso como sistemas de liberación de medicamentos (DDs), aún existen parámetros relacionados con su estabilidad estructural y sus rutas de procesamiento que han retrasado su aplicación realista en este campo. Ambos inconvenientes se resuelven en este trabajo para el bioMOF microporoso CaSyr-1, mediante el uso de CO2 supercrítico (scCO2) para cargar el bioMOF con el medicamento antituberculoso isoniazida (INH) y funcionalizar su superficie externa con una capa protectora hidrofóbica de estearato (S). El vehículo hidrofobizado CaSyr-1(INH)/S se recubre además con un surfactante neutro (PS60) para mejorar la humectabilidad del sistema. Se realizan pruebas in vitro, relacionadas con la biocompatibilidad del portador de medicamentos y la liberación del medicamento en fluidos simulados del cuerpo, para demostrar el potencial de los DDs diseñados en farmacia. El producto sintetizado mostró total biocompatibilidad incluso a altas concentraciones, y el tamaño de las partículas y la tasa de disolución resultaron adecuados para la administración pulmonar.
3729048
{3729048:KK6Q76XZ}
1
nature
50
default
1
1
title
1721
http://www.biomateriales.ictp.csic.es/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22KK6Q76XZ%22%2C%22library%22%3A%7B%22id%22%3A3729048%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Rosado%20et%20al.%22%2C%22parsedDate%22%3A%222024-11-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20%5C%22%3E%5Cn%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3ERosado%2C%20A.%20%3Ci%3Eet%20al.%3C%5C%2Fi%3E%20%3Ca%20class%3D%27zp-ItemURL%27%20target%3D%27_blank%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0896844624002870%27%3ESupercritical%20CO2%20assisted%20bioMOF%20drug%20encapsulation%20and%20functionalization%20for%20delivery%20with%20a%20synergetic%20therapeutic%20value%3C%5C%2Fa%3E.%20%3Ci%3EThe%20Journal%20of%20Supercritical%20Fluids%3C%5C%2Fi%3E%20106452%20%282024%29%20%3Ca%20class%3D%27zp-DOIURL%27%20target%3D%27_blank%27%20href%3D%27http%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.supflu.2024.106452%27%3Ehttp%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.supflu.2024.106452%3C%5C%2Fa%3E.%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27http%3A%5C%2F%5C%2Fwww.biomateriales.ictp.csic.es%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D3729048%26amp%3Bitem_key%3DKK6Q76XZ%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Supercritical%20CO2%20assisted%20bioMOF%20drug%20encapsulation%20and%20functionalization%20for%20delivery%20with%20a%20synergetic%20therapeutic%20value%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Albert%22%2C%22lastName%22%3A%22Rosado%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luis%22%2C%22lastName%22%3A%22Garc%5Cu00eda-Fern%5Cu00e1ndez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mar%5Cu00eda%20Rosa%22%2C%22lastName%22%3A%22Aguilar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rosa%20Ana%22%2C%22lastName%22%3A%22Ram%5Cu00edrez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ana%20M.%22%2C%22lastName%22%3A%22L%5Cu00f3pez-Periago%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jos%5Cu00e9%20A.%22%2C%22lastName%22%3A%22Ayll%5Cu00f3n%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Concepci%5Cu00f3n%22%2C%22lastName%22%3A%22Domingo%22%7D%5D%2C%22abstractNote%22%3A%22Despite%20the%20impressive%20characteristics%20of%20biological%20metal%20organic%20frameworks%20%28bioMOFs%29%20for%20their%20use%20as%20drug%20delivery%20systems%20%28DDs%29%2C%20there%20are%20still%20some%20parameters%20related%20to%20their%20structural%20stability%20and%20processing%20routes%20that%20have%20decelerated%20their%20realistic%20application%20in%20this%20field.%20Both%20drawbacks%20are%20unraveled%20in%20this%20work%20for%20the%20microporous%20bioMOF%20CaSyr-1%20by%20using%20supercritical%20CO2%20%28scCO2%29%20to%20load%20the%20bioMOF%20with%20the%20anti-tubercular%20isoniazid%20%28INH%29%20drug%2C%20and%20functionalize%20its%20external%20surface%20with%20a%20hydrophobic%20protective%20layer%20of%20stearate%20%28S%29.%20The%20hydrophobicized%20CaSyr-1%28INH%29%5C%2FS%20vehicle%20is%20further%20coated%20with%20a%20neutral%20surfactant%20%28PS60%29%20to%20enhance%20the%20wettability%20of%20the%20system.%20In%20vitro%20tests%2C%20related%20to%20drug%20carrier%20biocompatibility%20and%20drug%20release%20in%20body%20simulated%20fluids%2C%20are%20performed%20to%20demonstrate%20potential%20prospective%20of%20the%20designed%20DDs%20in%20pharmacy.%20The%20synthetized%20product%20displayed%20total%20biocompatibility%20even%20at%20high%20concentrations%2C%20and%20the%20particle%20size%20and%20dissolution%20rate%20showed%20to%20be%20adequate%20for%20pulmonary%20administration.%22%2C%22date%22%3A%222024-11-05%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.supflu.2024.106452%22%2C%22ISSN%22%3A%220896-8446%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0896844624002870%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222024-11-07T13%3A44%3A21Z%22%7D%7D%5D%7D
