Core expertise
The activity of the Group is divided into two main lines of research: the development of new systems for the encapsulation and controlled release of bioactive and therapeutical molecules and the development of new scaffolds for tissue engineering. Both lines continually converge, giving rise to high-performance biomaterials and medical devices.
Patents to license-out
- Biocompatible hydrogel, its preparation and use procedure (PCT/ES2018/070667)
- Self-associated functional acrylic copolymers and terpolymers and their use as vehicles for bioactive compounds (P201830594/EP3800)
- Naproxen/dexamethasone based nanoparticles (EP20382234)
Active or ongoing projects of the Group
- Development of advanced dental implants that combine osteoinductive and antibacterial properties in the dental field (Autonomous Community of Madrid (CAM) and company J. Ripoll S.L. Ref. IND2018/BMD-9485).
- Biphasic hydrogels for osteochondral regeneration: a novel approach through 3D bioprinting. (PICS2019 CSIC and CNRS)
- Interdisciplinary Platform of the CSIC on plastics for a circular economy, SUSPLAST (CSIC).
- Bioinspired materials for tissue engineering and controlled release of bioactive components. (Ministry of Science and Innovation, Ref. MAT2017-84277-R).
- Design and development of injectable polymer formulations for the treatment of osteoarthritis (Autonomous Community of Madrid (CAM) and Alodia Farmaceutica. Industrial doctorate, Ref. IND2017/IND-7614).
- Preparation and application of ear drops for the inhibition of sensorineural hearing loss (CIBER-BBN Technology Transfer Program (CIBER-BBN and Alodia Farmaceutica; Ref. NADEAFNESS).
Industry partnership and commercialization
The Group has a clear vocation for technology transfer as demonstrated by the multiple collaborations with the pharmaceutical and medical device industry (Alodia Pharmaceutica, LVD, J. Ripoll S.L.). Furthermore, the group actively participates as a co-founder member, in the CSIC interdisciplinary platform entitled “Plastics towards a circular economy” (SusPlast).
Interested in find investor or financial partner for:
- Preclinical studies of bioactive polymeric nanoparticles (i.e. anti-inflamatory, anticancer, antimicrobial capacity).
- Design and commercialization of hydrogels for osteochondral regeneration.
- Polymeric coatings for drug or molecule release with application in health and the environment
We can participate as partners for a project:
H2020 and Horizon Europe programmes, International projects for scientific cooperation, National projects as “Plan Nacional”, “RETOS-colaboración” and Community of Madrid (CAM) projects, focused on:
- Synthesis and preparation of monomers with pharmacological activity (anti-thrombogenic, anti-inflammatory, anti-tumor, anti-angiogenic, etc.)
- Synthesis and preparation of bioactive polymers with specific therapeutic action.
- Synthesis of nanostructured polymers for the preparation of self-assembled systems that favor the transport and release of bioactive molecules (i.e. drugs, vitamins, iRNA, growth factors, etc)
- Modification of natural polymers for the development of hydrogels scaffolds with bioactive properties (i.e. antioxidant capacity)
- Development of advanced therapies based on the design of bioactive polymeric scaffolds or composites for the treatment of various pathologies (gradient polymeric scaffolds, 3D printing).
- Study of the biological effect of biomaterials developed in eukaryotic and prokaryotic cells. Determination of cytotoxicity and biocompatibility, studies of inflammation, cancer and apoptosis. Determination of antibacterial activity.
Consulting service in:
- Design of polymeric nanoparticles as controlled drug release systems.
- Modification of natural polymers (chitosan, hyaluronic acid, etc.) for application in the field of biomedicine.
- Preparation of polymeric scaffolds incorporating cells and biological components using different techniques (3D bio/printing, electrospinning, cryopolymerization).
- Biological behavior of different types of materials by leading studies in cell cultures.
Analysis service:
The Biomaterials group has the EXPERTISSUES QA CERTIFICATE awarded by the EU EXPERTISSUES Network of Excellence. Our facilities have advanced techniques for the synthesis and characterization of polymers as well as two cell culture laboratories hosting the following analyses:
- Physical-chemical characterization of polymeric systems. Spectroscopic techniques: NMR (solid and liquid state), RAMAN, FTIR, UV-Vis, Fluorescence, Nanodrop; Microscopies: optics, epifluorescence, FE-SEM, ESEM, TEM, cryo-TEM, AFM; Calorimetric techniques: DSC, TGA, DMTA; Chromatographic techniques: GPC, HPLC; Rheology technique. Others: Zetasizer Nano ZS, X-ray diffraction, polymer processing techniques).
- Study of the in vitro biological effect of biomaterials developed in eukaryotic and prokaryotic cells. Determination of cytotoxicity and biocompatibility, studies of inflammation, cancer and apoptosis. Determination of antibacterial activity.