TY - JOUR TI - Novel non-cytotoxic, bioactive and biodegradable hybrid materials based on polyurethanes/TiO2 for biomedical applications AU - González-García, Dulce M. AU - Téllez Jurado, L. AU - Jiménez-Gallegos, R. AU - Rodríguez-Lorenzo, Luis M. T2 - Materials Science and Engineering: C AB - Titanium compounds have demonstrated great interfacial properties with biological tissues whereas a wide variety of polyurethanes have also been successfully probed in medical applications. However, studies about hybrids based on polyurethanes/TiO2 for medical applications are scarce. The aim of this work is to design novel biodegradable hybrid materials based on polyurethanes/TiO2 (80% organic–20% inorganic) and to perform a preliminary study of the potential applications in bone regeneration. The hybrids have been prepared by a sol-gel reaction using titanium isopropoxide as precursor of the inorganic component and polyurethane as the organic one. A series of polyurethanes has been prepared using different polyesters glycol succinate as soft segment, and 1,6-diisocyanatohexane (HDI) and butanediol (BD) as linear hard segment. The spectroscopy techniques used allow to confirm the formation of the required polyurethanes by the identification of bands related to carboxylic groups (COOH), and the amine groups (NH), and also the TiOH bonds and the bonds related to the interconnected network between the inorganic and the organic components from hybrids. The results from SEM/EDS show a homogeneous distribution of the inorganic component into the organic matrix. The nontoxic character of the hybrid (H400) was probed using MG-63 cell line with over 90% of cell viability. Finally, the formation of a hydroxyapatite layer in the material surface after 21 days of soaking in SBF shows the bioactive character. DA - 2017/06/01/ PY - 2017 DO - 10.1016/j.msec.2017.02.041 DP - ScienceDirect VL - 75 SP - 375 EP - 384 J2 - Materials Science and Engineering: C SN - 0928-4931 UR - http://www.sciencedirect.com/science/article/pii/S0928493116310001 Y2 - 2017/06/02/07:35:55 KW - Biodegradable KW - Hybrid material KW - Non-cytotoxic ER -