TY - JOUR TI - Polylactic-co-glycolic acid microspheres added to fixative cements and its role on bone infected architecture AU - Ibarra, Blanca AU - García-García, Joaquin AU - Azuara, Galo AU - Vázquez-Lasa, Blanca AU - Ortega, Miguel A. AU - Asúnsolo, Ángel AU - San Román, Julio AU - Buján, Julia AU - García-Honduvilla, Natalio AU - De la Torre, Basilio T2 - Journal of Biomedical Materials Research Part B: Applied Biomaterials AB - Abstract Joint prostheses are an essential element to improve quality of life. However, prostheses may fail due to several factors, including the most frequent cause, Staphylococcus aureus infection. The identification of new fixing bone cements with less reactivity on bone tissue and an adequate response to infection remains a primary challenge. The aim of this study is to evaluate the response of bone tissue in rabbits after introduction of a hydroxyapatite-coated titanium rod with a commercial fixative cement (Palacos?) compared to a modified experimental cement (EC) containing polylactic-co-glycolic acid (PLGA) microspheres in the presence or absence of contaminating germs. This study used 20 New Zealand rabbits which were divided into four groups (n?=?5) depending on the presence or absence of S. aureus and the use of commercial (Palacos?) or EC. A histological method, based on bone architecture damage, was proposed to evaluate from 1 to 9 the histological results and the response of the infected tissue. The macrophage response was also evaluated using monoclonal antibody RAM-11. The study showed better bone conservation with the use of EC with PLGA microspheres against the Palacos? commercial cement, including the noncontaminated and contaminated groups. ? 2019 The Authors. Journal of Biomedical Materials Research Part B: Applied Biomaterials published by Wiley Periodicals, Inc. J Biomed Mater Res Part B: 00B: 000?000, 2019. DA - 2019/02/19/ PY - 2019 DO - 10.1002/jbm.b.34342 DP - onlinelibrary.wiley.com (Atypon) VL - 0 IS - 0 J2 - Journal of Biomedical Materials Research Part B: Applied Biomaterials SN - 1552-4973 UR - https://onlinelibrary.wiley.com/doi/full/10.1002/jbm.b.34342 Y2 - 2019/03/21/09:36:02 KW - PLGA microspheres KW - biomaterials KW - macrophagic response KW - osteomyelitis KW - regenerative medicine ER -