TY - JOUR TI - Osteochondral angiogenesis and promoted vascularization: New therapeutic target AU - García-Fernández, L. T2 - Advances in Experimental Medicine and Biology AB - The control of the different angiogenic process is an important point in osteochondral regeneration. Angiogenesis is a prerequisite for osteogenesis in vivo; insufficient neovascularization of bone constructs after scaffold implantation resulted in hypoxia and cellular necrosis. Otherwise, angiogenesis must be avoided in chondrogenesis; vascularization of the cartilage contributes to structural damage and pain. Finding a balance between these processes is important to design a successful treatment for osteochondral regeneration. This chapter shows the most important advances in the control of angiogenic process for the treatment of osteochondral diseases focused on the administration of pro- or anti-angiogenic factor and the design of the scaffold. © Springer International Publishing AG, part of Springer Nature 2018. DA - 2018/// PY - 2018 DO - 10.1007/978-3-319-76735-2_14 DP - Scopus VL - 1059 SP - 315 EP - 330 ST - Osteochondral angiogenesis and promoted vascularization UR - https://link.springer.com/chapter/10.1007%2F978-3-319-76735-2_14 DB - Scopus KW - Angiogenic factors KW - Biomaterials KW - Neovascularization KW - Osteochondral angiogenesis KW - Osteochondral regeneration ER -